Projects
Light triggering of drug carrier systems for targeted delivery and controlled release
Project code: PN-II-ID-PCE-2011-3-0922
Ctr. No: 71/2011
Funded by: MEN-CD, UEFISCDI
Program: Ideas PCE
Contractor: National Institute of Lasers, Plasma and Radiation Physics
Project Leader: Dr. Angela Staicu
Start Date: October, 2011
End Date: December, 2016
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- Stage 1. Analytical synthesis regarding the new compounds development, establishing the impact factors that have to be taken into account. (October – December 2011)
- Potential compound components (linkers, photosenzitizers, drugs) analysis and selection
- Analysis and selection of relevant physical and chemical constants & impact factors (irradiation beam parameters).
- The parameters of the experimental set-ups for time resolved spectroscopy adjustment for investigation of the compounds.
- Report (in Romanian)
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- Stage2. Photophysical and photochemical studies on PS and linkers compounds (January-December 2012
Photophysical and photochemical studies of some PS molecules – phtalocyanines and porphyrins and linker molecules – olefinic type. Studies consisted on:
- Absorption spectroscopy measurements; photostability of the compounds under visible radiation.
- Laser induced fluorescence measurements, dispersed fluorescence spectra, fluorescence quantum yield.
- Measurements of the generated active species (oxygen singlet): singlet oxygen quantum yields, singlet oxygen quenching rates.
- Compound structure evolution (via vibrational bands) under visible radiation. Potential stable by-products generated by irradiation. IR spectroscopy analysis.
- Report ( in Romanian)
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- Stage3. Photophysical and photochemical properties of the PS-linkers and drug compounds (January-December 2013)
Photophysical and photochemical studies of some PS – linker (dye-olefins) compounds and drugs (phenotiazine):
- Study of the compounds hydrophylicity by measuring the surface tension
- Study by absorption spectroscopy measurements on the photostability of the compounds function of irradiation parameters
- Laser induced fluorescence measurements, dispersed fluorescence spectra, and quantum yield.
- Flash photolysis measurements of triplet state quantum yield and lifetime of triplet state for the compounds of interest
- Measurements of the generated active species (oxygen singlet): singlet oxygen quantum yields, singlet oxygen quenching rates.
- IR spectroscopy analysis of potential stable by-products generated by visible irradiation.
- Report (in Romanian)
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- Stage 4 Photophysical and photochemical properties of the SWCNT – PS compounds
(January-December 2014)
Synthesis and characterization of SWCNT conjugates with porphyrin derivatives. Photophysical and photochemical study consisting in:
- Study by absorption spectroscopy measurements on the photostability of the compounds
- Study of the compounds fluidity by measuring the surface tension, viscosity properties
- Laser induced fluorescence measurements, dispersed fluorescence spectra, and fluorescence quantum yield.
- Measurements of the generated active species (oxygen singlet): singlet oxygen quantum yields, singlet oxygen quenching rates.
- FTIR/Raman spectroscopy studies. Compounds structure analysis (via vibrational bands).
- Report (in Romanian)
- Stage 5 Photophysical and photochemical properties of the PS-SWCNT- Linker-Drug compounds
(January-December 2015)
- Study by absorption spectroscopy measurements of the compounds.
- Study of the compounds fluidity by measuring the surface tension.
- Laser induced fluorescence measurements.
- Measurements of the generated active species (oxygen singlet).
- Raman spectroscopy studies (compounds structure analysis)
- Report (in Romanian)
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- Stage 6 Photophysical and photochemical study of unirradiated and irradiated PS-CNT-Linker-Drug compounds. Optimal parameters for experimental set-ups and irradiation system.
(January-December 2016)
- Study of the compounds by absorption spectroscopy, transient absorption (triplet states lifetime, quantum yield), phosphorescence of the generated singlet oxygen (life time, quantum yield), FTIR spectroscopy (structural modification by irradiation).
- Optimal parameters for experimental set-ups and irradiation system (wavelength, energy, irradiation dose, fluence rate, samples concentrations)
- Report (in Romanian)
