Laser Spectroscopy Group

Projects

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Light triggering of drug carrier systems for targeted delivery and controlled release

Papers

T. Alexandru, A. Staicu, A. Pascu, A. Dinache, A.B. Abdeladhim, M. Enescu, A.Khatyr, M.L. Pascu, Light cleavage of some potential linkers for drug carriers,Rom. Rep. Phys. 68(2),673, 2016.
A. Smarandache, A. Pascu, I.R. Andrei, J. Handzlik, N. Kiec-Kononowicz, A. Staicu, M.L. Pascu, Study of the optical properties of 2-thiohydantoin derivatives, Rom. Rep. Phys. 68(2), 684, 2016.
B. Sjöberg, S. Foley, A. Staicu, A. Pascu, M. Pascu, M. Enescu, Protein reactivity with singlet oxygen: Influence of the solvent exposure of the reactive amino acid residues, J. Photochem. Photobiol. B. 159, 106-110, 2016.
A. Smarandache, V. Nastasa, M. Boni, A. Staicu, J. Handzlik, K. Kiec-Kononowicz, L. Amaral, M.L. Pascu, Laser beam resonant interaction of new hydantoin derivatives droplets for possible biomedical applications,Colloid Surf. A-Physicochem. Eng. 505, 37–46, 2016.
V. Nastasa, A. Pascu, M. Boni, A. Smarandache, A. Staicu, M.L. Pascu, Insights into the photophysics of zinc phthalocyanine and photogenerated singlet oxygen in DMSO-water mixture, Colloid Surf. A-Physicochem. Eng. 505, 197–203, 2016.
M. Boni, A. Staicu, I.R. Andrei, A. Smarandache, V. Nastasa, M. Comor, Z. Saponjic, M.L. Pascu, Studies on laser induced emission of microdroplets containing Rhodamine 6G solutions in water doped with TiO2 nanoparticles, Colloid Surf. A-Physicochem. Eng., http://dx.doi.org/10.1016/j.colsurfa.2016.07.033
Morán, MC; Tozar, T; Simon, A; Dinache, A; Smarandache, A; Andrei,IR; Boni, M; Pascu, ML; Cirisano, F; Ferrari, M; "Toxicity study in blood and tumor cells of laser produced medicines for application in fabrics"; Colloids and surfaces B: Bioninterfaces, 137: 91-103 (2016).
I. R. Andrei, T. Tozar, A. Dinache, M. Boni, V. Nastasa, M. L. Pascu, Chlorpromazine transformation by exposure to ultraviolet laser beams in droplet and bulk, European Journal of Pharmaceutical Sciences, 81, 27-35, 2016
A. Staicu, A. Pascu, V. Nastasa, M. L. Pascu, Photophysics of covalent functionalized single walled carbon nanotubes with a porphyrin-type photosensitizer, Romanian Reports in Physics, 67 (4), 2015
T. Alexandru, A. Staicu, A. Pascu, E. Radu, A. Stoicu, V. Nastasa, A. Dinache, M. Boni, L. Amaral, M. L. Pascu, Characterization of mixtures of compounds produced in Chlorpromazine aqueous solutions by UV laser irradiation: their applications in antimicrobial assays, Jurnal of Biomedical Optics, 20(5), 051002, 2015.
A. Dinache, M. Boni, T. Alexandru , E. Radu, A. Stoicu, I. R. Andrei, A. Staicu, L. Liggieri, V. Nastasa, M. L. Pascu, M. Ferrari, Surface properties of Vancomycin after interaction with laser beams, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 450, 328-335, 2015.
M. C. Moran, T. Tozar, A. Simon, A. Dinache, A. Smarandache, I. R. Andrei, M. Boni, M. L. Pascu, F. Cirisano, M. Ferrari,Toxicity study in blood and tumor cells of laser produced medicines for application in fabrics, online Colloids and Surfaces B: Biointerfaces, 2015
Adriana Smarandache, Agota Simon, Tatiana Tozar, Viorel Nastasa, Mihail Lucian Pascu,Stability studies on Promethazine unexposed and exposed to UV laser radiation, Proceedings of SPIE, 9549, 954916-1-9, 2015.
M. Boni, V. Nastasa, Angela Staicu, I.R. Andrei, M.L. Pascu, Characterisation of fluorescent pendant droplets, Romanian Reports in Physics, 67 (4), 2015
A. Smarandache, A. Staicu, V. Nastasa, J. Moreno-Moraga, J.R. De La Torre, M. Trelles, M.L. Pascu,Physical properties of laser irradiated sclerosing foams, Romanian Reports in Physics, 67 (4), 2015
T. Tozar, A. Stoicu, E. Radu, M. L. Pascu, Evaluation of thin layer chromatography image analysis method for irradiated chlorpromazine quantification, Romanian Reports in Physics, 67 (4), 2015
M. Boni, V. Nastasa, I. R. Andrei, Angela Staicu and M. L. Pascu, Enhanced fluorescence emitted by microdroplets containing organic dye emulsions, , Biomicrofluidics, 9, 014126 (2015)
T. Alexandru, A. Staicu, A. Pascu, E. Radu, A. Stoicu, V. Nastasa, A. Dinache, M. Boni, L. Amaral, M. L. Pascu, Characterization of mixtures of compounds produced in Chlorpromazine aqueous solutions by UV laser irradiation: their applications in antimicrobial assays, Journal of Biomedical Optics, 20(5):051002. doi: 10.1117/1.JBO.20.5.051002, 2015.
V. Nastasa, K Samaras, ML Pascu, T.D. Karapantsios, Moderately stable emulsions produced by a double syringe method, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 460, 321, 2014.
A. Simon, T. Alexandru, M. Boni, V. Damian, A. Stoicu, V. Dutschk, M. L. Pascu, Interaction of solutions containing phenothiazines exposed to laser radiation with materials surfaces, in view of biomedical applications, International Journal of Pharmaceutics, 475, 270, 2014.
A. Dinache, M. Boni, T. Alexandru, E. Radu, A. Stoicu, I. Andrei, A. Staicu, L. Liggieri, V. Nastasa, M. Ferrari, M. L. Pascu, Surface properties of Vancomycin after interaction with laser beams, accepted for publication in Colloids and Surfaces A: Physicochemical and Engineering Aspects , 2014.
A. Staicu, A. Pascu, M.Boni, M.L. Pascu, M. Enescu, Photophysical study of Zn phthalocyanine in binary solvent mixtures, J. Molec. Struct. 1044, 188, 2013.
M. L. Pascu, B. Danko, A. Martins, N. Jedlinszki, T. Alexandru, V. Nastasa, M. Boni, A. Militaru, I. R. Andrei, A. Staicu, A. Hunyadi, S. Fanning, L. Amaral, Exposure of chlorpromazine to 266 nm laser beam generates new species with antibacterial properties: contributions to the development of a new process for drug discovery, PLoS ONE, 8(2), e55767, 2013.
A. Staicu, A. Pascu, A. Nuta, M. L. Pascu, A. Sorescu, V. Raditoiu, Studies about phthalocyanine photosensitizers to be used in photodynamic therapy, Rom. Rep. Phys. 65, 1032, 2013.
M. Boni, V. Nastasa, A.Militaru, A. Smarandache, I.R. Andrei, G.V. Popescu, A. Staicu, M.L. Pascu, Laser beams interaction with liquids in optofluidic experiments, Rom. Rep. Phys. 64, 1179, 2012.

Conferences

M. Boni, I R Andrei, A Staicu, M. L. Pascu, Lasing effects in microvolumetric droplets pumped by laser beams, EMN Droplets 2016 Conference, San Sebastian, Spania, 10 – 13 May, 2016.
A. Dinache, A. Smarandache, T. Alexandru, A. Pascu, V. Nastasa, A. Simon, M. Enescu, A. Khatyr, F. Sima, M.L. Pascu, A. Staicu, Photosensitized cleavage of some olefins as potential linkers to be used in drug delivery, 10th International Conference on Photoexcited Processes and Applications (ICPEPA-10), Brasov, Romania, August 29 – September 2, 2016.
A. Smarandache, A. Pascu, M. Boni, I. Andrei, J. Handzlik, K. Kiec-Kononowicz, A. Staicu, M.L. Pascu, Spectroscopic investigations of novel pharmaceuticals: stability and laser beam resonant interaction, 10th International Conference on Photoexcited Processes and Applications (ICPEPA-10), Brasov, Romania, August 29 – September 2, 2016.
A. Staicu, A. Pascu, A. Smarandache, T. Alexandru, M.L. Pascu, Photophysics of single wall carbon nanotubes covalently functionalised with porphyrin photosensitizers, 10th International Conference on Photoexcited Processes and Applications (ICPEPA-10), Brasov, Romania, August 29 – September 2, 2016.
I.R. Andrei, M. Boni, A. Staicu, M.L. Pascu, Fluorescence emission structure of a side-pumped Rh6G dye doped micro-droplet, 10th International Conference on Photoexcited Processes and Applications (ICPEPA-10), Brasov, Romania, August 29 – September 2, 2016.
V. Nastasa, M. Boni, I.R. Andrei, A. Staicu, M.L. Pascu, Enhanced fluorescence emission of pendant micro-droplets containig emulsions , 6th International Workshop on Bubble and Drop Interfaces (B&D2015) Pstsdam-Golm, Germany, July 06-10,2015.
T. Tozar, A. Dinache, V. Nastasa, M. Boni, A. Simon, M.L.Pascu, Antimicrobial activity of UV photgenerated non-antibiotic drug in fighting multidrug resistance bacteria, New frontiers in regenerative medicine and surgery. Interdisciplinarity, research and clinical applications Congress, Bucharest, Romania, 12, 15- 16 May 2015
T. Tozar, A. Stoicu, V. Nastasa, M. Popa, I. R. Andrei, M. C. Chifiriu, M. L. Pascu, Testing the susceptibility of bacteria in planktonic and biofilms forms to fenotiazines exposed to a 266 nm laser beam emitted by a Nd:YAG laser, Annual Scientific Conference of Faculty of Physics, 19 June 2015, Magurele, Romania
M. Boni, V. Nastasa, I.R. Andrei, A. Staicu, M.L. Pascu, Comparison between emission spectra of pendant droplets containing dye solutions and emulsions, Annual Scientific Conference of Faculty of Physics, Magurele, Romania, 19 June 2015.
M.Boni, V.Nastasa, I.R.Andrei, A.Staicu, M.L. Pascu, Lasing emission by microdroplets of emulsion, Smart and green interfaces - Conference, March 2015, Belgrade, Serbia (oral presentation).
A. Staicu , A. Dinache, A. Smarandache, T. Tozar, A. Pascu, V. Nastasa, M. Boni, A. Simon , I. R. Andrei , M. Enescu , M. L. Pascu, Photophysical studies of some compounds of interest in targeted drug delivery, 11th International Conference Micro- to Nano-Photonics IV - ROMOPTO, September 1-4, 2015
Adriana Smarandache, Angela Staicu , V. Nastasa, J. Moreno-Moraga, J. Royo de la Torre , M. Trelles, M. L. Pascu, Physical properties of laser irradiated sclerosing foams, 11th International Conference Micro- to Nano-Photonics IV - ROMOPTO, September 1-4, 2015.
I.R. Andrei , M. Boni, A. Staicu, M.L. Pascu, Lasing emission by side-pumped dye-doped droplets in pendant positions: modal structure, 11th International Conference Micro- to Nano-Photonics IV - ROMOPTO, September 1-4, 2015.
A. Dinache, T. Tozar, M. Boni, A. Staicu, V. Nastasa, A. Stoicu, I.R. Andrei, V. Damian, E. Radu, M. Ferrari, M. L. Pascu (2015), Smart and green interfaces- Conference , Belgrade, Serbia, 31 March - 1 April 2015.
Adriana Smarandache, Angela Staicu, V. Nastasa, J. Moreno-Moraga, J. Royo de la Torre, M. Trelles, M.L.Pascu, Laser irradiated Polidocanol foam for sclerotherapy, The First ISRMS congress: New frontieres in regenerative medicine and surgery. Interdisciplinarity, research and clinical applications(ISRMS), Buchraest, Romania, 12, 15-16 May 2015.
A. Smarandache, A. Pascu, M. Boni, I. Andrei, J. Handzlik, K. Kiec-Kononowicz, A. Staicu, M.-L. Pascu, Spectroscopic investigations of new hydantoin derivatives and their behavior under laser beam exposure for further biomedical applications, 6th Congress of International PhotoTherapy Association (IPTA 6th), Nice, France, 9-10 July 2015.
M. Boni, I.R. Andrei , V. Nastasa , Angela Staicu , M.L. Pascu, Lasing Emission by Side-pumped Emulsion Droplets in Pendant Positions, Progress In Electromagnetics Research Symposium (PIERS 2015), Prague, July 6-9, 2015.
I.R. Andrei, A. Baleanu, M.L. Pascu, Chaotic low-frequency fluctuations of the laser radiation emitted by a diode laser working at currents above the laser threshold, Progress In Electromagnetics Research Symposium (PIERS 2015), Praga, Cehia, July 6-9, 2015.
Adriana Smarandache, M. Boni, V. Nastasa, I. R. Andrei, J. Handzlik, K. Kiec-Kononowicz,L. Amaral, M.L. Pascu; Laser beam resonant interaction of new hydantoin derivatives droplets for biomedical applications; B&D 2015, Potsdam, Germany, 06-10 July 2015
Adriana Smarandache, Mihai Boni, Viorel Nastasa, Ionut R. ANDREI, Jadwiga Handzlik, Katarzyna KIEC-KONONOWICZ, Leonard AMARAL, Mihail Lucian PASCU; Investigations on the interaction of unexplored hydantoin derivatives solutions with optical beams Annual Scientific Conference of Faculty of Physics, University of Bucharest, Magurele, Romania,June 19, 2015.
Adriana Smarandache, Agota Simon, Andra Dinache, Tatiana Tozar, Mihai Boni, Ionut R. ANDREI, M. Carmen MORĂN, Francesca CIRISANO, Michele FERRARI, Mihail Lucian PASCU; Stability of new laser produced medicines in view of their application on biomedical fabrics Annual Scientific Conference of Faculty of Physics, University of Bucharest, Magurele, Romania,June 19, 2015.
A. Smarandache, V. Nastasa, M. Boni, J. Handzlik, K. Kiec-Kononowicz, L. Amaral, M.L. Pascu; Light exposure influence on the wetting properties of new imidazolidine derivatives solutions; 5th International Colloids Conference 2015 Colloid and Interface Sciences for a Brighter Future, Amsterdam, Olanda, 21-24,06,2015.
M. Boni, Angela Staicu, I.R. Andrei, Adriana Smarandache, V. Nastasa, Z. Saponjic, M.-L. Pascu, Studies on the laser induced emission of microdroplets containing Rhodamine 6G solutions in water doped with TiO2 nanoparticles, Smart and green interfaces: Fundamentals and diagnostics (SGI-FunD), Sofia, Bulgaria, 29-31 October 2015.
M.Boni, V.Nastasa, I.R.Andrei, A.Staicu, M.L. Pascu, Laser induced emission of dye emulsion droplets, Smart and green interfaces: Fundamentals and diagnostics (SGI-FunD), Sofia, Bulgaria, 29-31 Octomber 2015.
I.R. Andrei, A. Baleanu, M.L. Pascu, Chaotic low-frequency fluctuations of the radiation emitted by a semiconductor laser working at currents above the laser threshold, Annual Scientific Conference of Faculty of Physics, University of Bucharest, Magurele, Romania, June 19, 2015.
Agota Simon, Tatiana Tozar, M. Boni, V. Damian, Victoria Dutschk, M.L. Pascu, Biomedical applications of non-antibiotics exposed to UV laser radiation and their interaction with fabric surfaces, The First ISRMS congress: New frontieres in regenerative medicine and surgery. Interdisciplinarity, research and clinical applications(ISRMS), Bucharest, Romania, 12 & 15- 16 May 2015.
Agota SIMON, Tatiana TOZAR, Alexandru Stoicu, Mihai Boni, Victor Damian, Mihail-Lucian Pascu,Biomedical applications of laser exposed medicines containing solutions in interaction with target surfaces: "ESA Spin Your Thesis!" programme, Annual Scientific Conference of Faculty of Physics, University of Bucharest, Magurele, Romania,June 19, 2015.
A. Simon, T. Tozar, A. Stoicu, M. Boni, V. Damian, M.L. Pascu, Interaction of laser exposed non-antibiotic solutions with target surfaces, in view of biomedical applications: ESA Spin Your Thesis! campaign, 11th International Conference Micro- to Nano-Photonics IV- ROMOPTO 2015, Bucharest, Romania, 1-4 September 2015.
Agota Simon, Adriana Smarandache, Tatiana Tozar, Viorel Nastasa, Ruxandra Pirvulescu, Mihail Lucian Pascu, Stability studies on Promethazine unexposed and exposed to UV laser radiation, Optics + Photonics, San Diego, USA, 8-12 August 2015 .

Mihai Boni, Viorel Nastasa, Angela Staicu, Ionut Relu Andrei, Mihail-Lucian Pascu, Lasing efects on opticaly pumped micro-droplets, Seventeenth International School on Quantum Electronics:"Laser Physics and Applications 2012", 24-28 September, Nessebar, Bulgaria. (poster presentation).
M.L. Pascu, A. Militaru, M. Boni, T. Alexandru, V. Nastasa, I. R. Andrei, Laser methods used to fight multiple drug resistance to treatment, 26th Congress Laser Medicine, 9-10 November 2012, Firenze, Italy. (invited presentation).
T. Alexandru, A. Staicu, A. Pascu, A. Dinache, A.B. Abdeladhim, M. Enescu, A.Khatyr, M.L. Pascu, Light cleavage of some potential linkers for drug carriers, Sesiunea Stiintifica a Facultatii de Fizica, Univ. Bucuresti, June 2014, oral presentation.
T. Smarandache, A. Dinache, A. Pascu, I. Andrei, J. Handzlik, K. Kiec-Kononowicz, A. Staicu, M.L. Pascu, Spectroscopic investigations of new anticancer drugs and their behavior at the incidence with laser radiation, SPEC 2014 Shedding New Light on Disease, Krakow, Poland, 17-22 August 2014, oral presentation.
A. Staicu, A. Dinache, T. Alexandru, A. Pascu, A. Smarandache, V. Nastasa, M. Boni, A. Simon, F. Sima, M. Enescu, M. L. Pascu, Photodynamic studies of some molecules of interest in drug carrier systems, 5th edition of International Student Conference on Photonics (ISCP 2014), Orastie, 23-26 September 2014, invited presentation.
M. Boni, V. Nastasa, I.R. Andrei, A. Staicu, M.L. Pascu, Enhanced fluorescence in pending micro-droplets that contain emulsions, oral presentation.
A. Dinache, M. Boni, A. Staicu, T. Alexandru, E. Radu, V. Nastasa, A. Stoicu, I. Andrei, V. Damian, M. Ferrari, M. L. Pascu, Spectral evidence of Vancomycin’s modification under exposure to laser radiation, 5th edition of International Student Conference on Photonics (ISCP 2014), Orastie, 23-26 September 2014, oral presentation.
I.R. Andrei, T. Alexandru, M. Boni, A. Dinache, V. Nastasa, M.L. Pascu, Characterization of laser radiation interaction with liquid droplets and bulk that contain solution of chlorpromazine in water, 5th edition of International Student Conference on Photonics (ISCP 2014), Orastie, 23-26 September 2014, oral presentation.
T. Alexandru, A. Staicu, A. Pascu, A. Dinache, M. Enescu, A. Khatyr, M. L. Pascu, Singlet oxygen interaction with some olefins as potential linkers in targeted drug delivery, 5th edition of International Student Conference on Photonics (ISCP 2014), Orastie, 23-26 September 2014, poster presentation.
A. Stoicu, A. Dinache, M.L. Pascu, Analogy of Vancomycin experimental and model spectra, 5th edition of International Student Conference on Photonics (ISCP 2014), Orastie, 23-26 September 2014, poster presentation.

T. Alexandru, A. Staicu, V. Nastasa, A. Pascu, A. Dinache, A. Smarandache, A. Simon, E. Radu, M. Enescu, M. L. Pascu, Laser induced cleavage of molecules for application on biological targets, Biophotonics'13, 6th International Graduate Summer School, 8-15 June 2013, Island of Ven, Sweden (poster presentation).
T. Alexandru, V. Nastasa, A. Staicu, E. Radu, A. Stoicu, M. L. Pascu, Studies of the interaction of UV laser radiation whit non-antibiotics using optical and non-optical techniques, Sesiunea Stiinţifică Anuală a Facultăţii de Fizică, 21 June, Magurele, Romania (oral presentation).
T. Alexandru, V. Nastasa, A. Staicu, M. L. Pascu, FTIR studies of Phenotiazines exposed to laser beam, INDLAS & ISCP 2013, 20-24 May 2013, Bran, Romania (oral presentation).
A. Staicu, A. Pascu, M. Enescu and M.L. Pascu, "Photophysical study of Zn Phthalocyanine in solvent mixtures", 31st European Congress on Molecular Spectroscopy (EUCMOS 2012), August 2012, Cluj-Napoca, Romania (poster presentation).
A. Staicu, A. Pascu, M. Boni, T. Alexandru, M. Enescu, M.L. Pascu, "Spectroscopical studies of zinc phthalocyanine in binary solvent mixtures", International Conference on Optics "Micro- to Nano-Photonics III- ROMOPTO 2012", September 2012 Bucharest, Romania (poster presentation).
T. Alexadru, M. L. Pascu, A. Armada, B. Danko, V. Nastasa, M. Boni, A. Militaru, I. R. Andrei, A. Staicu, A. Hunyadi, M. Viveiros, L. Amaral , Activity of irradiated Chlorpromazine with a 266 nm laser beam against efflux pumps system / prezentare orala, Exploratory Workshop 2012 "Emerging Analytical to Investigate Nitro-oxidative Stress, Bucuresti, Romania, July, 2012 (oral presentation)
T. Alexandru, M. L. Pascu, B. Danko, V. Nastasa, M. Boni, A. Militaru, I. R. Andrei, A. Staicu, A. Hunyadi, A. Armada, M. Viveiros, L. Amaral, Generation and biological evaluation of the products formed from the exposure of Chlorpromazine to a 266 nm laser beam , International Conference "Micro- to Nano-Photonics III- ROMOPTO 2012, Bucuresti, Romania, 3-6 September, 2012 (poster presentation),
M. Boni, V. Nastasa, I.R Andrei, Angela Staicu, M. L. Pascu , Lasing effects in micro droplets, International Conference on Optics "Micro- to Nano-Photonics III- ROMOPTO 2012", 3-6 September, Bucharest, Romania (poster presentation).