Light triggering of drug carrier systems for targeted delivery and controlled release

Project code: PN-II-ID-PCE-2011-3-0922

Ctr. No: 71/2011

Funded by: MEN-CD, UEFISCDI

Program: Ideas PCE

Contractor: National Institute of Lasers, Plasma and Radiation Physics

Project Leader: Dr. Angela Staicu Start Date: October, 2010 End Date: October, 2016

 

Stage 6 (January-Octomber 2016)

Photophysical and photochemical properties of the PT-SWCNT- Linker-Drug compounds (II). Influence of optical irradiation parameters, sample concentration, and environment over the active species generation and reaction rates

 

Stage 5 (January-December 2015)

Photophysical and photochemical properties of the PT-SWCNT- Linker-Drug compounds 

Study by absorption spectroscopy measurements of the compounds. Study of the compounds fluidity by measuring the surface tension. Laser induced fluorescence measurements. Measurements of the generated active species (oxygen singlet). Raman spectroscopy studies (compounds structure analysis). Report (in Romanian)

 

Stage 4 (January-December 2014)

Photophysical and photochemical properties of the SWCNT – PS compounds 

Synthesis and characterization of SWCNT conjugates with porphyrin derivatives. Photophysical and photochemical study consisting in: Study by absorption spectroscopy measurements on the photostability of the compounds Study of the compounds fluidity by measuring the surface tension, viscosity properties Laser induced fluorescence measurements, dispersed fluorescence spectra, and fluorescence quantum yield. Measurements of the generated active species (oxygen singlet): singlet oxygen quantum yields, singlet oxygen quenching rates. FTIR/Raman spectroscopy studies. Compounds structure analysis (via vibrational bands). Report (in Romanian)

 

Stage 3 (January-December 2013)

Photophysical and photochemical properties of the PS-linkers and drug compounds

Photophysical and photochemical studies of some PS – linker (dye-olefins) compounds and drugs (phenotiazine): Study of the compounds hydrophylicity by measuring the surface tension Study by absorption spectroscopy measurements on the photostability of the compounds function of irradiation parameters Laser induced fluorescence measurements, dispersed fluorescence spectra, and quantum yield. Flash photolysis measurements of triplet state quantum yield and lifetime of triplet state for the compounds of interest Measurements of the generated active species (oxygen singlet): singlet oxygen quantum yields, singlet oxygen quenching rates. IR spectroscopy analysis of potential stable by-products generated by visible irradiation. Report (in Romanian)

 

Stage 2 (January-December 2012)

Photophysical and photochemical studies on PS and linkers compounds

Photophysical and photochemical studies of some PS molecules – phtalocyanines and porphyrins and linker molecules – olefinic type. Studies consisted on: Absorption spectroscopy measurements; photostability of the compounds under visible radiation. Laser induced fluorescence measurements, dispersed fluorescence spectra, fluorescence quantum yield. Measurements of the generated active species (oxygen singlet): singlet oxygen quantum yields, singlet oxygen quenching rates. Compound structure evolution (via vibrational bands) under visible radiation. Potential stable by-products generated by irradiation. IR spectroscopy analysis. Report ( in Romanian)

 

Stage 1 (OCtober-December 2011)

Analytical synthesis regarding the new compounds development, establishing the impact factors that have to be taken into account.

Potential compound components (linkers, photosenzitizers, drugs) analysis and selection Analysis and selection of relevant physical and chemical constants & impact factors (irradiation beam parameters). The parameters of the experimental set-ups for time resolved spectroscopy adjustment for investigation of the compounds. Report (in Romanian)